Limiting the Spread

Tracking Resistance

Improving Stewardship

Developing New Solutions

A Targeted Approach to Reducing Surgical Site Infections

Routine molecular testing of the nares for the presence of Staphylococcus aureus followed by targeted decolonization of patients carrying either S. aureus (SA) or Methicillin-resistant S. aureus (MRSA) prior to surgery is an effective strategy for preventing surgical site infections (SSIs).1,2,3 It is consistent with both infection prevention and antimicrobial stewardship efforts. This article provides an overview of the value of presurgical molecular testing and targeted decolonization at reducing post–joint replacement SSIs.

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1. Bode LG, et al. Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med. 2010;362:9-17.
2. Jain R, et al. Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections. N Engl J Med. 2011;364:1419-30.
3. van Rijen MML, et al. Reduced Costs for Staphylococcus aureus Carriers Treated Prophylactically with Mupirocin and Chlorhexidine in Cardiothoracic and Orthopaedic Surgery. PLoS One. 2012;7:e43065.

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